Benchtop and Animal Validation of a Projective Imaging System for Potential Use in Intraoperative Surgical Guidance
Identifieur interne : 001364 ( Main/Exploration ); précédent : 001363; suivant : 001365Benchtop and Animal Validation of a Projective Imaging System for Potential Use in Intraoperative Surgical Guidance
Auteurs : Qi Gan [République populaire de Chine] ; Dong Wang [République populaire de Chine, États-Unis] ; Jian Ye [République populaire de Chine] ; Zeshu Zhang [République populaire de Chine] ; Xinrui Wang [République populaire de Chine] ; Chuanzhen Hu [République populaire de Chine] ; Pengfei Shao [République populaire de Chine] ; Ronald X. Xu [République populaire de Chine, États-Unis]Source :
- PLoS ONE [ 1932-6203 ] ; 2016.
Abstract
We propose a projective navigation system for fluorescence imaging and image display in a natural mode of visual perception. The system consists of an excitation light source, a monochromatic charge coupled device (CCD) camera, a host computer, a projector, a proximity sensor and a Complementary metal–oxide–semiconductor (CMOS) camera. With perspective transformation and calibration, our surgical navigation system is able to achieve an overall imaging speed higher than 60 frames per second, with a latency of 330 ms, a spatial sensitivity better than 0.5 mm in both vertical and horizontal directions, and a projection bias less than 1 mm. The technical feasibility of image-guided surgery is demonstrated in both agar-agar gel phantoms and an ex vivo chicken breast model embedding Indocyanine Green (ICG). The biological utility of the system is demonstrated in vivo in a classic model of ICG hepatic metabolism. Our benchtop, ex vivo and in vivo experiments demonstrate the clinical potential for intraoperative delineation of disease margin and image-guided resection surgery.
Url:
DOI: 10.1371/journal.pone.0157794
PubMed: 27391764
PubMed Central: 4938571
Affiliations:
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Wang</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Department of Precision Machinery and Precision Instrumentation, University of Science and Technology of China, Hefei, Anhui, People’s Republic of China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Precision Machinery and Precision Instrumentation, University of Science and Technology of China, Hefei, Anhui</wicri:regionArea><wicri:noRegion>Anhui</wicri:noRegion></affiliation><affiliation wicri:level="2"><nlm:aff id="aff002"><addr-line>Department of Biomedical Engineering, The Ohio State University, Columbus, Ohio, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biomedical Engineering, The Ohio State University, Columbus, Ohio</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Ye, Jian" sort="Ye, Jian" uniqKey="Ye J" first="Jian" last="Ye">Jian Ye</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Department of Precision Machinery and Precision Instrumentation, University of Science and Technology of China, Hefei, Anhui, People’s Republic of China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Precision Machinery and Precision Instrumentation, University of Science and Technology of China, Hefei, Anhui</wicri:regionArea><wicri:noRegion>Anhui</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Zeshu" sort="Zhang, Zeshu" uniqKey="Zhang Z" first="Zeshu" last="Zhang">Zeshu Zhang</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Department of Precision Machinery and Precision Instrumentation, University of Science and Technology of China, Hefei, Anhui, People’s Republic of China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Precision Machinery and Precision Instrumentation, University of Science and Technology of China, Hefei, Anhui</wicri:regionArea><wicri:noRegion>Anhui</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Xinrui" sort="Wang, Xinrui" uniqKey="Wang X" first="Xinrui" last="Wang">Xinrui Wang</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Department of Precision Machinery and Precision Instrumentation, University of Science and Technology of China, Hefei, Anhui, People’s Republic of China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Precision Machinery and Precision Instrumentation, University of Science and Technology of China, Hefei, Anhui</wicri:regionArea><wicri:noRegion>Anhui</wicri:noRegion></affiliation></author><author><name sortKey="Hu, Chuanzhen" sort="Hu, Chuanzhen" uniqKey="Hu C" first="Chuanzhen" last="Hu">Chuanzhen Hu</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Department of Precision Machinery and Precision Instrumentation, University of Science and Technology of China, Hefei, Anhui, People’s Republic of China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Precision Machinery and Precision Instrumentation, University of Science and Technology of China, Hefei, Anhui</wicri:regionArea><wicri:noRegion>Anhui</wicri:noRegion></affiliation></author><author><name sortKey="Shao, Pengfei" sort="Shao, Pengfei" uniqKey="Shao P" first="Pengfei" last="Shao">Pengfei Shao</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Department of Precision Machinery and Precision Instrumentation, University of Science and Technology of China, Hefei, Anhui, People’s Republic of China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Precision Machinery and Precision Instrumentation, University of Science and Technology of China, Hefei, Anhui</wicri:regionArea><wicri:noRegion>Anhui</wicri:noRegion></affiliation></author><author><name sortKey="Xu, Ronald X" sort="Xu, Ronald X" uniqKey="Xu R" first="Ronald X." last="Xu">Ronald X. Xu</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Department of Precision Machinery and Precision Instrumentation, University of Science and Technology of China, Hefei, Anhui, People’s Republic of China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Precision Machinery and Precision Instrumentation, University of Science and Technology of China, Hefei, Anhui</wicri:regionArea><wicri:noRegion>Anhui</wicri:noRegion></affiliation><affiliation wicri:level="2"><nlm:aff id="aff002"><addr-line>Department of Biomedical Engineering, The Ohio State University, Columbus, Ohio, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biomedical Engineering, The Ohio State University, Columbus, Ohio</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>We propose a projective navigation system for fluorescence imaging and image display in a natural mode of visual perception. The system consists of an excitation light source, a monochromatic charge coupled device (CCD) camera, a host computer, a projector, a proximity sensor and a Complementary metal–oxide–semiconductor (CMOS) camera. With perspective transformation and calibration, our surgical navigation system is able to achieve an overall imaging speed higher than 60 frames per second, with a latency of 330 ms, a spatial sensitivity better than 0.5 mm in both vertical and horizontal directions, and a projection bias less than 1 mm. The technical feasibility of image-guided surgery is demonstrated in both agar-agar gel phantoms and an ex vivo chicken breast model embedding Indocyanine Green (ICG). The biological utility of the system is demonstrated in vivo in a classic model of ICG hepatic metabolism. Our benchtop, ex vivo and in vivo experiments demonstrate the clinical potential for intraoperative delineation of disease margin and image-guided resection surgery.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Apantaku, Lm" uniqKey="Apantaku L">LM Apantaku</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Weber, Wp" uniqKey="Weber W">WP Weber</name></author><author><name sortKey="Engelberger, S" uniqKey="Engelberger S">S Engelberger</name></author><author><name sortKey="Viehl, Ct" uniqKey="Viehl C">CT Viehl</name></author><author><name sortKey="Zanetti Dallenbach, R" uniqKey="Zanetti Dallenbach R">R Zanetti-Dallenbach</name></author><author><name sortKey="Kuster, S" uniqKey="Kuster S">S Kuster</name></author><author><name sortKey="Dirnhofer, S" uniqKey="Dirnhofer S">S Dirnhofer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Smitt, Mc" uniqKey="Smitt M">MC 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Gan</name></noRegion><name sortKey="Hu, Chuanzhen" sort="Hu, Chuanzhen" uniqKey="Hu C" first="Chuanzhen" last="Hu">Chuanzhen Hu</name><name sortKey="Shao, Pengfei" sort="Shao, Pengfei" uniqKey="Shao P" first="Pengfei" last="Shao">Pengfei Shao</name><name sortKey="Wang, Dong" sort="Wang, Dong" uniqKey="Wang D" first="Dong" last="Wang">Dong Wang</name><name sortKey="Wang, Xinrui" sort="Wang, Xinrui" uniqKey="Wang X" first="Xinrui" last="Wang">Xinrui Wang</name><name sortKey="Xu, Ronald X" sort="Xu, Ronald X" uniqKey="Xu R" first="Ronald X." last="Xu">Ronald X. Xu</name><name sortKey="Ye, Jian" sort="Ye, Jian" uniqKey="Ye J" first="Jian" last="Ye">Jian Ye</name><name sortKey="Zhang, Zeshu" sort="Zhang, Zeshu" uniqKey="Zhang Z" first="Zeshu" last="Zhang">Zeshu Zhang</name></country><country name="États-Unis"><region name="Ohio"><name sortKey="Wang, Dong" sort="Wang, Dong" uniqKey="Wang D" first="Dong" last="Wang">Dong Wang</name></region><name sortKey="Xu, Ronald X" sort="Xu, Ronald X" uniqKey="Xu R" first="Ronald X." last="Xu">Ronald X. Xu</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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